OVERVIEW OF NCCN CLINICAL PRACTICE GUIDELINES
IN ONCOLOGY (NCCN GUIDELINES®)

OVERVIEW OF NCCN CLINICAL PRACTICE GUIDELINES IN ONCOLOGY (NCCN GUIDELINES®)

Treatment landscape for first-line squamous mNSCLC. Adapted from the NCCN Guidelines®1a
  • a Current as of November 2017.
Overview of National Comprehensive Cancer Network® Guidelines for Stage IV Advanced NSCLC - chart Overview of National Comprehensive Cancer Network® Guidelines for Stage IV Advanced NSCLC - chart
  • b PD-L1 testing recommended. For patients with squamous cell carcinoma, consider EGFR mutation and ALK testing in never smokers or small biopsy specimens or mixed histology. Consider ROS-1 and BRAF testing. For adenocarcinoma, large cell or NSCLC NOS, EGFR, ALK, ROS-1, and BRAF testing should be performed. Testing should be performed as part of broad molecular profiling. Patients positive for an actionable mutation (EGFR, ALK, ROS-1, or BRAF) first-line treatment with the appropriate targeted agent is recommended.
  • c For patients who are EGFR, ALK, ROS-1, and BRAF mutation negative.
  • d PD-L1 expression levels of ≥50% are a positive test result for first-line pembrolizumab therapy.
  • e PS 0-2; for patients who are PS 3 or 4, best supportive care is recommended.
  • Adapted with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Small CelI Lung Cancer V.9.2017. © National Comprehensive Cancer Network, Inc. 2017. All rights reserved. Accessed July 14, 2017. To view the most recent and complete version of the guideline, go online to NCCN.org.
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