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ITT and by Histology

The most common ARs (≥20%) of ABRAXANE in combination with carboplatin are anemia, neutropenia, thrombocytopenia, alopecia, peripheral neuropathy, nausea, and fatigue.
ABRAXANE + carboplatin delivered
significantly superior ORR vs paclitaxel:
ITT population8
ABRAXANE (100 mg/m2 IV weekly on Days 1, 8, and 15 of each 21-day cycle) + carboplatin (AUC=6 mg•min/mL IV Day 1 of each 21-day cycle) (n=170/521); 95% CI: 28.6%-36.7%
Paclitaxel injection (200 mg/m2 IV, Day 1 of each 21-day cycle) + carboplatin (AUC=6 mg•min/mL IV, Day 1 of each 21-day cycle) (n=132/531); 95% CI: 21.2%-28.5%
P=0.005 (based on chi-square test).
ARs=adverse reactions; AUC=area under the curve; ITT=intent-to-treat; NS=not significant; ORR=overall response rate; OS=overall survival.
41% ORR in first-line squamous:
Squamous population
ABRAXANE + carboplatin
(n=94/229)
Paclitaxel injection + carboplatin
(n=54/221)
Response rate in other histologies
P=0.005 (based on chi-square test).
ARs=adverse reactions; AUC=area under the curve; ITT=intent-to-treat; NS=not significant; ORR=overall response rate; OS=overall survival.
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The clinical trial described in this article served as the
basis for the approval for ABRAXANE for Injectable Suspension.
The analyses contained in the article may differ from those in the package insert for ABRAXANE.
Please see Important Safety Information and Prescribing Information, including Boxed WARNING.
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The clinical trial described in this article served as the
basis for the approval for ABRAXANE for Injectable Suspension.
The analyses contained in the article may differ from those in the package insert for ABRAXANE.
Please see Important Safety Information and Prescribing Information, including Boxed WARNING.
Click “OK” to proceed or “CANCEL” to return to
www.abraxanepro.com
Click “OK” to proceed or “CANCEL” to return to
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